I took this original shot at 6400 ISO with lots of noise:
And using Topaz DeNoise converted the shot to this:
Topaz DeNoise allows one to get rid of the noise without destroying the clarity of the photograph.
If you click on each of the images they will open in a separate window where you can examine the larger image. I am particularly happy with her whiskers which still maintain their detail, rather than turning into a blurry mess (which is usually what happens with most “remove grain/noise” options in processing software).